Solid-Phase Parallel Synthesis of Drug-Like Artificial 2<em>H</em>-Benzopyran Libraries

Abstract

This review covers the construction of drug-like 2<em>H</em>-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran derivatives and additional ring-fused benzopyrans such as benzopyranoisoxazoles, benzopyranopyrazoles, six-membered ring-fused benzopyrans, and polycyclic benzopyrans are highlighted.

Keywords

• combinatorial chemistry
• solid-phase synthesis
• chemical library
• drug-like molecules
• 2&lt;em&gt;H&lt;/em&gt;-benzopyran