Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles

Abstract

Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight-membered exo-palladacycles with broad substrate scope.