Nature Communications (Jul 2021)
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing
- Georgios I. Laliotis,
- Evangelia Chavdoula,
- Maria D. Paraskevopoulou,
- Abdul Kaba,
- Alessandro La Ferlita,
- Satishkumar Singh,
- Vollter Anastas,
- Keith A. Nair,
- Arturo Orlacchio,
- Vasiliki Taraslia,
- Ioannis Vlachos,
- Marina Capece,
- Artemis Hatzigeorgiou,
- Dario Palmieri,
- Christos Tsatsanis,
- Salvatore Alaimo,
- Lalit Sehgal,
- David P. Carbone,
- Vincenzo Coppola,
- Philip N. Tsichlis
Affiliations
- Georgios I. Laliotis
- Department of Cancer Biology and Genetics, The Ohio State University
- Evangelia Chavdoula
- Department of Cancer Biology and Genetics, The Ohio State University
- Maria D. Paraskevopoulou
- Molecular Oncology Research Institute, Tufts Medical Center
- Abdul Kaba
- Department of Cancer Biology and Genetics, The Ohio State University
- Alessandro La Ferlita
- Department of Cancer Biology and Genetics, The Ohio State University
- Satishkumar Singh
- The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- Vollter Anastas
- Department of Cancer Biology and Genetics, The Ohio State University
- Keith A. Nair
- Department of Cancer Biology and Genetics, The Ohio State University
- Arturo Orlacchio
- Department of Cancer Biology and Genetics, The Ohio State University
- Vasiliki Taraslia
- Molecular Oncology Research Institute, Tufts Medical Center
- Ioannis Vlachos
- DIANA-Lab, Hellenic Pasteur Institute
- Marina Capece
- Department of Cancer Biology and Genetics, The Ohio State University
- Artemis Hatzigeorgiou
- DIANA-Lab, Hellenic Pasteur Institute
- Dario Palmieri
- Department of Cancer Biology and Genetics, The Ohio State University
- Christos Tsatsanis
- School of Medicine, University of Crete
- Salvatore Alaimo
- Department of Clinical and Experimental Medicine, Bioinformatics Unit, University of Catania
- Lalit Sehgal
- The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- David P. Carbone
- The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- Vincenzo Coppola
- Department of Cancer Biology and Genetics, The Ohio State University
- Philip N. Tsichlis
- Department of Cancer Biology and Genetics, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-021-24795-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 25
Abstract
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK-dependent pathway.
