Nature Communications (Nov 2019)

A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

  • M. Ilcim Thestrup,
  • Sara Caviglia,
  • Jordi Cayuso,
  • Ronja L. S. Heyne,
  • Racha Ahmad,
  • Wolfgang Hofmeister,
  • Letizia Satriano,
  • David G. Wilkinson,
  • Jesper B. Andersen,
  • Elke A. Ober

DOI
https://doi.org/10.1038/s41467-019-13149-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting cellular rearrangements leading to an open tube.