Frontiers in Cell and Developmental Biology (Mar 2022)

Association of Impaired Fasting Blood Glucose With Triple Coronary Artery Stenosis and Myocardial Infarction Among Patients With Coronary Artery Stenosis

  • Chang Chen,
  • Yequn Chen,
  • Jiaxin Xiao,
  • Yanhong Zhang,
  • Zhaorui Yang,
  • Peixuan Yang,
  • Nan Lu,
  • Kaihong Yi,
  • Xiaojun Chen,
  • Shaoxin Chen,
  • Mary Clare O'Gara MSc,
  • Michael O'Meara,
  • Shu Ye,
  • Shu Ye,
  • Shu Ye,
  • Xuerui Tan,
  • Xuerui Tan

DOI
https://doi.org/10.3389/fcell.2022.820124
Journal volume & issue
Vol. 10

Abstract

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Background: The association between impaired fasting glucose level (IFG) and coronary heart disease (CAD) remain controversial. In the present study, we sought to ascertain a relationship of IFG with the number of diseased coronary artery and occurrence of myocardial infarction, among CAD cases.Methods: We studied 1,451 consecutive no-diabetic patients who underwent coronary angiography at the First Affiliated Hospital of Shantou University Medical College in Southern China. Demographic, biochemical, clinical and angiographic data were collected.Results: The prevalence of IFG was higher in patients with angiographically confirmed CAD than in subjects without angiographic evidence of CAD (33.4 versus 28.2%, p = 0.034). Compared with CAD cases without IFG, CAD cases with IFG had a higher odds ratio (OR) of having triple-vessel disease as opposed to having single- or double-vessel disease [OR = 1.53, 95% confidence interval (CI) = 1.13–2.07]. Furthermore, the occurrence of MI was higher in CAD cases with IFG than in CAD cases without IFG (OR = 1.73, 95% CI = 1.27–2.36).Conclusions: There is an association between IFG and a predisposition to severe CAD indicated by triple vessel disease or myocardial infarction.

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