Nature Communications (Jan 2019)
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation
- Sarah C. Starossom,
- Juliana Campo Garcia,
- Tim Woelfle,
- Silvina Romero-Suarez,
- Marta Olah,
- Fumihiro Watanabe,
- Li Cao,
- Ada Yeste,
- John J. Tukker,
- Francisco J. Quintana,
- Jaime Imitola,
- Franziska Witzel,
- Dietmar Schmitz,
- Markus Morkel,
- Friedemann Paul,
- Carmen Infante-Duarte,
- Samia J. Khoury
Affiliations
- Sarah C. Starossom
- Institute for Medical Immunology, Charité – Universitätsmedizin Berlin
- Juliana Campo Garcia
- Institute for Medical Immunology, Charité – Universitätsmedizin Berlin
- Tim Woelfle
- Institute for Medical Immunology, Charité – Universitätsmedizin Berlin
- Silvina Romero-Suarez
- Institute for Medical Immunology, Charité – Universitätsmedizin Berlin
- Marta Olah
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Fumihiro Watanabe
- Laboratory of Neural Stem Cells and Functional Neurogenetics, Department of Neurology-The Ohio State University Wexner Medical Center
- Li Cao
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Ada Yeste
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- John J. Tukker
- Neuroscience Research Center (NWFZ), Charité – Universitätsmedizin Berlin
- Francisco J. Quintana
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Jaime Imitola
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Franziska Witzel
- IRI Life Sciences, Institute of Pathology, Computational Modeling in Medicine, Charité– Universitätsmedizin Berlin
- Dietmar Schmitz
- NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin
- Markus Morkel
- Institute of Pathology, Laboratory of Molecular Tumor Pathology and Systems Biology, Charité – Universitätsmedizin Berlin
- Friedemann Paul
- Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin
- Carmen Infante-Duarte
- Institute for Medical Immunology, Charité – Universitätsmedizin Berlin
- Samia J. Khoury
- Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-018-08140-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Chitinase 3-like-3 (Chi3l3) is expressed in microglia, but its function is not clear. Here the authors show that Chi3l3 is expressed in the subventricular zone in mouse experimental immune encephalitis, which induces oligodendrogenesis.
