Nature Communications (Jun 2021)

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

  • Chrysanthi Taxiarchi,
  • Andrea Beaghton,
  • Nayomi Illansinhage Don,
  • Kyros Kyrou,
  • Matthew Gribble,
  • Dammy Shittu,
  • Scott P. Collins,
  • Chase L. Beisel,
  • Roberto Galizi,
  • Andrea Crisanti

DOI
https://doi.org/10.1038/s41467-021-24214-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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Technologies that can halt the spread of gene drives would be highly useful in controlling or reverting their effect. Here the authors use the anti-CRISPR protein AcrIIA4 to inactivate drives in A. gambiae.