APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression

Abstract

Ribose-5-phosphate (R5P) is required for DNA synthesis, but how this is regulated during cell cycle progression is unclear. Here the authors report that the cell cycle regulator APC/C-CDH1 synchronizes cell cycle progression with R5P-derived DNA synthesis by controlling TKTL1 stability