Nature Communications (Aug 2020)
Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF
- Hongri Gong,
- Yan Gao,
- Xiaoting Zhou,
- Yu Xiao,
- Weiwei Wang,
- Yanting Tang,
- Shan Zhou,
- Yuying Zhang,
- Wenxin Ji,
- Lu Yu,
- Changlin Tian,
- Sin Man Lam,
- Guanghou Shui,
- Luke W. Guddat,
- Luet-Lok Wong,
- Quan Wang,
- Zihe Rao
Affiliations
- Hongri Gong
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- Yan Gao
- Laboratory of Structural Biology, Tsinghua University
- Xiaoting Zhou
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Yu Xiao
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Weiwei Wang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Yanting Tang
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- Shan Zhou
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- Yuying Zhang
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- Wenxin Ji
- National Laboratory of Biomacromolecules,omolecules, Institute of Biophysics, CAS
- Lu Yu
- High Magnetic Field Laboratory, Chinese Academy of Sciences
- Changlin Tian
- High Magnetic Field Laboratory, Chinese Academy of Sciences
- Sin Man Lam
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, CAS
- Guanghou Shui
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, CAS
- Luke W. Guddat
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Luet-Lok Wong
- Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford
- Quan Wang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Zihe Rao
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- DOI
- https://doi.org/10.1038/s41467-020-18011-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Diheme-containing succinate:menaquinone oxidoreductases (Sdh) are members of the complex II superfamily. Here, the authors present the 2.8 Å cryo-EM structure of Mycobacterium smegmatis Sdh2, which reveals membrane-anchored SdhF as a component of the complex and they discuss the electron/proton transfer pathway in the Sdh2 trimer.
