Nature Communications (May 2019)

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

  • Channakeshava Sokke Umeshappa,
  • Santiswarup Singha,
  • Jesus Blanco,
  • Kun Shao,
  • Roopa Hebbandi Nanjundappa,
  • Jun Yamanouchi,
  • Albert Parés,
  • Pau Serra,
  • Yang Yang,
  • Pere Santamaria

DOI
https://doi.org/10.1038/s41467-019-09893-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.