Nature Communications (Jul 2018)

Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

  • Zhiyong Liu,
  • Qiang Qin,
  • Cheng Wu,
  • Hui Li,
  • Jia’nan Shou,
  • Yuting Yang,
  • Meidi Gu,
  • Chunmei Ma,
  • Wenlong Lin,
  • Yan Zou,
  • Yuanyuan Zhang,
  • Feng Ma,
  • Jihong Sun,
  • Xiaojian Wang

DOI
https://doi.org/10.1038/s41467-018-05176-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.