Nature Communications (Jan 2020)

The RNA-binding protein HuR is a negative regulator in adipogenesis

  • Diana Teh Chee Siang,
  • Yen Ching Lim,
  • Aung Maung Maung Kyaw,
  • Khaing Nwe Win,
  • Sook Yoong Chia,
  • Ufuk Degirmenci,
  • Xiang Hu,
  • Bryan C. Tan,
  • Arcinas Camille Esther Walet,
  • Lei Sun,
  • Dan Xu

DOI
https://doi.org/10.1038/s41467-019-14001-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Human antigen R (HuR) is an RNA binding protein that promotes mRNA stability. Here the authors show that HuR represses adipogenesis in white and brown adipose tissue by stabilizing Insig1 and other targets.