TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand

Chan Seok Lim; Yoon Ha Jang; Ga Young Lee; Gu Min Han; Hye Jin Jeong; Ji Won Kim; Jie-Oh Lee

doi:10.1038/s41467-022-34602-0

Nature Communications (Nov 2022)

TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand

Chan Seok Lim,
Yoon Ha Jang,
Ga Young Lee,
Gu Min Han,
Hye Jin Jeong,
Ji Won Kim,
Jie-Oh Lee

Affiliations

Chan Seok Lim: Department of Life Sciences and POSTECH
Yoon Ha Jang: Department of Life Sciences and POSTECH
Ga Young Lee: Department of Life Sciences and POSTECH
Gu Min Han: Department of Life Sciences and POSTECH
Hye Jin Jeong: Institute of Membrane Proteins, POSTECH
Ji Won Kim: Department of Life Sciences and POSTECH
Jie-Oh Lee: Department of Life Sciences and POSTECH

DOI: https://doi.org/10.1038/s41467-022-34602-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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TLR3 plays a crucial role in anti-viral immune response by recognizing RNAs produced during virus infection. Here, the authors determine a high resolution structure of the activated cluster of TLR3. This structure will provide a platform for designing antiviral therapeutics and vaccines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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