Semaphorin 3A: A potential target for prevention and treatment of nickel allergy

Lipei Liu; Megumi Watanabe; Norikazu Minami; Mohammad Fadyl Yunizar; Tetsuo Ichikawa

doi:10.1038/s42003-022-03641-0

Communications Biology (Jul 2022)

Semaphorin 3A: A potential target for prevention and treatment of nickel allergy

Lipei Liu,
Megumi Watanabe,
Norikazu Minami,
Mohammad Fadyl Yunizar,
Tetsuo Ichikawa

Affiliations

Lipei Liu: Department of Prosthodontics & Oral Rehabilitation, Tokushima University, Graduate School of Biomedical Sciences
Megumi Watanabe: Department of Prosthodontics & Oral Rehabilitation, Tokushima University, Graduate School of Biomedical Sciences
Norikazu Minami: Department of Prosthodontics & Oral Rehabilitation, Tokushima University, Graduate School of Biomedical Sciences
Mohammad Fadyl Yunizar: Department of Prosthodontics & Oral Rehabilitation, Tokushima University, Graduate School of Biomedical Sciences
Tetsuo Ichikawa: Department of Prosthodontics & Oral Rehabilitation, Tokushima University, Graduate School of Biomedical Sciences

DOI: https://doi.org/10.1038/s42003-022-03641-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Semaphorin 3A is upregulated in keratinocytes upon nickel exposure, subsequently promoting Th1 cytokine responses and driving nickel allergic reactions.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal