P04.04 Single cell transcriptomics reveals cancer associated fibroblasts enable modeling of tumor associated macrophage like phenotypes and treatment responses in primary colorectal cancer organoid cultures

• A Chen,
• L Tran,
• M Bergmann,
• J Laengle,
• J Kabiljo,
• J Homola,
• H Walczak,
• N Hartman,
• G Egger,
• A Renner,
• H Dolznig,
• M Fabits,
• A Theophil,
• J Karall,
• S Stang,
• A Kulu,
• V Atanasova,
• D Herndler-Brandstetter,
• A Kusienicka,
• M Farlik

Affiliations

A Chen

5Medical University of Vienna, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Vienna, Austria

L Tran

Groupe Hospitalier Paris Saint Joseph,75014 Paris, France

M Bergmann

2Ludwig Boltzmann Institute Applied Diagnostics, Medical University of Vienna, Vienna, Austria

J Laengle

Medical University Vienna, Vienna, Austria

J Kabiljo

2Ludwig Boltzmann Institute Applied Diagnostics, Medical University of Vienna, Vienna, Austria

J Homola

1Division of General Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, Vienna, Austria

H Walczak

6CECAD Cluster of Excellence, University of Cologne, Cologne, Germany

N Hartman

1Barts Heart Centre, St Bartholomew’s Hospital, UK

G Egger

6Medical University of Vienna, Department of Pathology, Comprehensive Cancer Center Vienna, Vienna, Austria

A Renner

Medical University Vienna, Vienna, Austria

H Dolznig

Medical University Vienna, Vienna, Austria

M Fabits

Medical University Vienna, Vienna, Austria

A Theophil

2Ludwig Boltzmann Institute Applied Diagnostics, Medical University of Vienna, Vienna, Austria

J Karall

1Medical University of Vienna, Department of General Surgery, Comprehensive Cancer Center Vienna, Vienna, Austria

S Stang

4Medical University of Vienna, Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Austria, Vienna, Austria

A Kulu

3Medical University of Vienna, Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center Vienna, Vienna, Austria

V Atanasova

4Medical University of Vienna, Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Austria, Vienna, Austria

D Herndler-Brandstetter

5Medical University of Vienna, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Vienna, Austria

A Kusienicka

11Medical University of Vienna, Department of Dermatology, Vienna, Austria

M Farlik

11Medical University of Vienna, Department of Dermatology, Vienna, Austria