Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

Jessica Aijia Liu; Yanxia Rao; May Pui Lai Cheung; Man-Ning Hui; Ming-Hoi Wu; Lo-Kong Chan; Irene Oi-Lin Ng; Ben Niu; Kathryn S. E. Cheah; Rakesh Sharma; Louis Hodgson; Martin Cheung

doi:10.1038/s41467-017-01107-0

Nature Communications (Oct 2017)

Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

Jessica Aijia Liu,
Yanxia Rao,
May Pui Lai Cheung,
Man-Ning Hui,
Ming-Hoi Wu,
Lo-Kong Chan,
Irene Oi-Lin Ng,
Ben Niu,
Kathryn S. E. Cheah,
Rakesh Sharma,
Louis Hodgson,
Martin Cheung

Affiliations

Jessica Aijia Liu: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Yanxia Rao: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
May Pui Lai Cheung: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Man-Ning Hui: Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Ming-Hoi Wu: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Lo-Kong Chan: State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Irene Oi-Lin Ng: State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Ben Niu: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Kathryn S. E. Cheah: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Rakesh Sharma: Proteomics and Metabolomics Core Facility, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Louis Hodgson: Department of Anatomy and Structural Biology, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine
Martin Cheung: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong

DOI: https://doi.org/10.1038/s41467-017-01107-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

Read online

Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localized in the cytoplasm, governing neural crest migratory polarization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal