Molecules (Jun 2002)
Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
Abstract
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.
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