HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

Weili Miao; Lin Li; Yonghui Zhao; Xiaoxia Dai; Xuemei Chen; Yinsheng Wang

doi:10.1038/s41467-019-11552-8

Nature Communications (Aug 2019)

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

Weili Miao,
Lin Li,
Yonghui Zhao,
Xiaoxia Dai,
Xuemei Chen,
Yinsheng Wang

Affiliations

Weili Miao: Department of Chemistry, University of California Riverside
Lin Li: Department of Chemistry, University of California Riverside
Yonghui Zhao: Department of Botany and Plant Sciences, University of California Riverside
Xiaoxia Dai: Department of Chemistry, University of California Riverside
Xuemei Chen: Department of Botany and Plant Sciences, University of California Riverside
Yinsheng Wang: Department of Chemistry, University of California Riverside

DOI: https://doi.org/10.1038/s41467-019-11552-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced upregulation of DNAJB4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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