Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice

Nao Sankoda; Wataru Tanabe; Akito Tanaka; Hirofumi Shibata; Knut Woltjen; Tsutomu Chiba; Hironori Haga; Yoshiharu Sakai; Masaki Mandai; Takuya Yamamoto; Yasuhiro Yamada; Shinji Uemoto; Yoshiya Kawaguchi

doi:10.1038/s41467-021-20906-0

Nature Communications (Jan 2021)

Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice

Nao Sankoda,
Wataru Tanabe,
Akito Tanaka,
Hirofumi Shibata,
Knut Woltjen,
Tsutomu Chiba,
Hironori Haga,
Yoshiharu Sakai,
Masaki Mandai,
Takuya Yamamoto,
Yasuhiro Yamada,
Shinji Uemoto,
Yoshiya Kawaguchi

Affiliations

Nao Sankoda: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
Wataru Tanabe: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
Akito Tanaka: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
Hirofumi Shibata: Department of Otolaryngology, Gifu University Graduate School of Medicine
Knut Woltjen: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
Tsutomu Chiba: Department of Gastroenterology, Kyoto University Graduate School of Medicine
Hironori Haga: Department of Diagnostic Pathology, Kyoto University Hospital
Yoshiharu Sakai: Department of Surgery, Kyoto University Graduate School of Medicine
Masaki Mandai: Department of Gynecology and Obstetrics, Kyoto University Hospital
Takuya Yamamoto: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
Yasuhiro Yamada: Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo
Shinji Uemoto: Department of Surgery, Kyoto University Graduate School of Medicine
Yoshiya Kawaguchi: Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University

DOI: https://doi.org/10.1038/s41467-021-20906-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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