Nature Communications (May 2019)
Regeneration of severely damaged lungs using an interventional cross-circulation platform
- Brandon A. Guenthart,
- John D. O’Neill,
- Jinho Kim,
- Dawn Queen,
- Scott Chicotka,
- Kenmond Fung,
- Michael Simpson,
- Rachel Donocoff,
- Michael Salna,
- Charles C. Marboe,
- Katherine Cunningham,
- Susan P. Halligan,
- Holly M. Wobma,
- Ahmed E. Hozain,
- Alexander Romanov,
- Gordana Vunjak-Novakovic,
- Matthew Bacchetta
Affiliations
- Brandon A. Guenthart
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- John D. O’Neill
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Jinho Kim
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Dawn Queen
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Scott Chicotka
- Department of Surgery, Columbia University Medical Center, Columbia University
- Kenmond Fung
- Department of Clinical Perfusion, Columbia University Medical Center, Columbia University
- Michael Simpson
- Department of Surgery, Columbia University Medical Center, Columbia University
- Rachel Donocoff
- Institute of Comparative Medicine, Columbia University Medical Center, Columbia University
- Michael Salna
- Department of Surgery, Columbia University Medical Center, Columbia University
- Charles C. Marboe
- Department of Pathology and Cell Biology, Columbia University Medical Center, Columbia University
- Katherine Cunningham
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Susan P. Halligan
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Holly M. Wobma
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Ahmed E. Hozain
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Alexander Romanov
- Institute of Comparative Medicine, Columbia University Medical Center, Columbia University
- Gordana Vunjak-Novakovic
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- Matthew Bacchetta
- Department of Biomedical Engineering, Columbia University Medical Center, Columbia University
- DOI
- https://doi.org/10.1038/s41467-019-09908-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Gastric aspiration severely injures donor lungs, frequently making them unacceptable for transplantation. Here the authors show that an interventional cross-circulation platform enables the regeneration of severely damaged lungs in a swine model of gastric aspiration injury.
