Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Sio-Hong Lam; Po-Hsun Chen; Hsin-Yi Hung; Tsong-Long Hwang; Chih-Chao Chiang; Tran  Dinh Thang; Ping-Chung Kuo; Tian-Shung Wu

doi:10.3390/molecules23102541

Molecules (Oct 2018)

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Sio-Hong Lam,
Po-Hsun Chen,
Hsin-Yi Hung,
Tsong-Long Hwang,
Chih-Chao Chiang,
Tran Dinh Thang,
Ping-Chung Kuo,
Tian-Shung Wu

Affiliations

Sio-Hong Lam: School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Po-Hsun Chen: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Hsin-Yi Hung: School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chih-Chao Chiang: Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 338, Taiwan
Tran Dinh Thang: School of Chemistry, Biology and Environment, Vinh University, Vinh City 44000, Vietnam
Ping-Chung Kuo: School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Tian-Shung Wu: School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan

DOI: https://doi.org/10.3390/molecules23102541
Journal volume & issue: Vol. 23, no. 10
p. 2541

Abstract

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Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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