Nature Communications (Aug 2021)
Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis
- Yi Zhu,
- Na Li,
- Mingyang Huang,
- Mason Bartels,
- Sophie Dogné,
- Shangang Zhao,
- Xi Chen,
- Clair Crewe,
- Leon Straub,
- Lavanya Vishvanath,
- Zhuzhen Zhang,
- Mengle Shao,
- Yongjie Yang,
- Christy M. Gliniak,
- Ruth Gordillo,
- Gordon I. Smith,
- William L. Holland,
- Rana K. Gupta,
- Bingning Dong,
- Nathalie Caron,
- Yong Xu,
- Yucel Akgul,
- Samuel Klein,
- Philipp E. Scherer
Affiliations
- Yi Zhu
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Na Li
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Mingyang Huang
- Children’s Nutrition Research Center, Department of Pediatric, Baylor College of Medicine
- Mason Bartels
- Department of Plastic Surgery, The University of Texas Southwestern Medical Center at Dallas
- Sophie Dogné
- Molecular Physiology Research Unit, NARILIS, University of Namur
- Shangang Zhao
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Xi Chen
- Children’s Nutrition Research Center, Department of Pediatric, Baylor College of Medicine
- Clair Crewe
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Leon Straub
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Lavanya Vishvanath
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Zhuzhen Zhang
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Mengle Shao
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Yongjie Yang
- Children’s Nutrition Research Center, Department of Pediatric, Baylor College of Medicine
- Christy M. Gliniak
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Ruth Gordillo
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Gordon I. Smith
- Center for Human Nutrition, Washington University School of Medicine in St. Louis.
- William L. Holland
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Rana K. Gupta
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- Bingning Dong
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Nathalie Caron
- Molecular Physiology Research Unit, NARILIS, University of Namur
- Yong Xu
- Children’s Nutrition Research Center, Department of Pediatric, Baylor College of Medicine
- Yucel Akgul
- Department of Plastic Surgery, The University of Texas Southwestern Medical Center at Dallas
- Samuel Klein
- Center for Human Nutrition, Washington University School of Medicine in St. Louis.
- Philipp E. Scherer
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas
- DOI
- https://doi.org/10.1038/s41467-021-25025-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice fed high-fat diet and improves systemic glucose homeostasis.
