Nature Communications (Nov 2020)
PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
- Tanner O. Monroe,
- Melanie E. Garrett,
- Maria Kousi,
- Ramona M. Rodriguiz,
- Sungjin Moon,
- Yushi Bai,
- Steven C. Brodar,
- Karen L. Soldano,
- Jeremiah Savage,
- Thomas F. Hansen,
- Donna M. Muzny,
- Richard A. Gibbs,
- Lawrence Barak,
- Patrick F. Sullivan,
- Allison E. Ashley-Koch,
- Akira Sawa,
- William C. Wetsel,
- Thomas Werge,
- Nicholas Katsanis
Affiliations
- Tanner O. Monroe
- Department of Pediatrics, Northwestern University Feinberg School of Medicine
- Melanie E. Garrett
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Maria Kousi
- MIT Computer Science and Artificial Intelligence Laboratory (CSAIL), Broad Institute of MIT and Harvard
- Ramona M. Rodriguiz
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine
- Sungjin Moon
- Department of Biological Sciences, Kangwon National University
- Yushi Bai
- Department of Cell Biology, Duke University School of Medicine
- Steven C. Brodar
- Department of Cell Biology, Duke University School of Medicine
- Karen L. Soldano
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Jeremiah Savage
- Center for Translational Data Science, The University of Chicago
- Thomas F. Hansen
- Department of Clinical Sciences, University of Copenhagen
- Donna M. Muzny
- Human Genome Sequencing Center, Baylor College of Medicine
- Richard A. Gibbs
- Human Genome Sequencing Center, Baylor College of Medicine
- Lawrence Barak
- Department of Cell Biology, Duke University School of Medicine
- Patrick F. Sullivan
- Department of Genetics, University of North Carolina at Chapel Hill
- Allison E. Ashley-Koch
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Akira Sawa
- Department of Psychiatry, Johns Hopkins University School of Medicine
- William C. Wetsel
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine
- Thomas Werge
- Department of Clinical Sciences, University of Copenhagen
- Nicholas Katsanis
- Department of Pediatrics, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19637-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in human cohorts and zebrafish in vivo complementation suggests PCM1 mutations can contribute to schizophrenia.
