CHOLESTEROL PARADOX IN PATIENTS WITH CHRONIC CARDIAC INSUFFICIENCY MODERN STATE OF THE PROBLEM

Abstract

Chronic cardiac insufficiency (CCI) is a wide-spread disease among the population of the Russian Federation and, as a rule, it is related to presence of the ischemic heart disease (IHD). Hypercholesterinemia is the major risk factor of IHD development but, however paradoxical it might seem, IHD patients often present a low cholesterol level, which, in its turn, is associated with the bad forecast. Reduction of the cholesterol level by statins reduces the incidence and mortality rate in IHD patients without CCI and possible improves the forecast in patients with CCI. But results of a number of studies testify that the high cholesterol level in patients with CCI is associated with better survival rates. This article provides data on the cholesterol paradox in CCI patients, its possible mechanisms and modern algorithms of the above-stated patients group management.

Keywords

• cholesterol
• chronic cardiac insufficiency
• cholesterol paradox
• rosuvastatin