Zhongguo linchuang yanjiu (Dec 2023)

Effects of bifidobacterium tetragenous viable tablets on insulin sensitivity, intestinal microflora, glycolipid metabolism in type 2 diabetes mellitus

  • YANG Xiaoling,
  • MA Liang,
  • AN Min,
  • LI Yue,
  • SUN Wei

DOI
https://doi.org/10.13429/j.cnki.cjcr.2023.12.007
Journal volume & issue
Vol. 36, no. 12
pp. 1803 – 1806

Abstract

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Objective To explore the correlation between the prolongating PR interval of electrocardiogram and the general information and biochemical indicators of diabetes patients with microvascular complications, and the predictive value of diabetes microvascular complications. Methods A total of 217 patients with diabetes who hospitalized in Department of Endocrinology, Xi'an Third Hospital from August 2020 to November 2022 were selected retrospectively. Among them, 149 patients only with diabetes were divided into control group, while 68 diabetes patients with microvascular complications were divided into observation group. The general data and biochemical indexes of all diabetes patients were collected, and the PR interval was measured by standard 12 lead synchronous electrocardiograph. The correlation between PR interval and general data and biochemical indicators in patients with microvascular complications of diabetes were analyzed. The predictive value of PR interval on microvascular complications in diabetes was analyzed by receiver operating characteristic (ROC) curve. Results Age, duration of diabetes, body mass index (BMI), hemoglobin A1c (HbA1c), PR interval in the observation group were higher than those in the control group (P＜0.01). PR interval of diabetes patients with microvascular complications was positively correlated with age, diabetes duration, BMI, HbA1c (P＜0.01). The AUC of PR interval for predicting microvascular complications in diabetes was 0.812 (95%CI:0.752-0.872), the sensitivity was 70.6%, the specificity was 78.5%, and the cut-off value was 212.61 ms. Prolonged PR interval was an independent risk factor for microvascular complications in diabetes (OR=2.475, 95%CI: 1.472-5.120, P＜0.01). Conclusion In patients with microvascular complications of diabetes, the PR interval in electrocardiogrom is significantly prolonged. Prolonged PR interval is an independent risk factor for microvascular complications in diabetes, which is helpful to predict the occurance of diatetic microvascular complications.

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