Nature Communications (Oct 2022)
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype
- G. Tuba Barut,
- Nico Joel Halwe,
- Adriano Taddeo,
- Jenna N. Kelly,
- Jacob Schön,
- Nadine Ebert,
- Lorenz Ulrich,
- Christelle Devisme,
- Silvio Steiner,
- Bettina Salome Trüeb,
- Bernd Hoffmann,
- Inês Berenguer Veiga,
- Nathan Georges François Leborgne,
- Etori Aguiar Moreira,
- Angele Breithaupt,
- Claudia Wylezich,
- Dirk Höper,
- Kerstin Wernike,
- Aurélie Godel,
- Lisa Thomann,
- Vera Flück,
- Hanspeter Stalder,
- Melanie Brügger,
- Blandina I. Oliveira Esteves,
- Beatrice Zumkehr,
- Guillaume Beilleau,
- Annika Kratzel,
- Kimberly Schmied,
- Sarah Ochsenbein,
- Reto M. Lang,
- Manon Wider,
- Carlos Machahua,
- Patrick Dorn,
- Thomas M. Marti,
- Manuela Funke-Chambour,
- Andri Rauch,
- Marek Widera,
- Sandra Ciesek,
- Ronald Dijkman,
- Donata Hoffmann,
- Marco P. Alves,
- Charaf Benarafa,
- Martin Beer,
- Volker Thiel
Affiliations
- G. Tuba Barut
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Nico Joel Halwe
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Adriano Taddeo
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Jenna N. Kelly
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Jacob Schön
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Nadine Ebert
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Lorenz Ulrich
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Christelle Devisme
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Silvio Steiner
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Bettina Salome Trüeb
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Bernd Hoffmann
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Inês Berenguer Veiga
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Nathan Georges François Leborgne
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Etori Aguiar Moreira
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Angele Breithaupt
- Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Claudia Wylezich
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Dirk Höper
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Kerstin Wernike
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Aurélie Godel
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Lisa Thomann
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Vera Flück
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Hanspeter Stalder
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Melanie Brügger
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Blandina I. Oliveira Esteves
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Beatrice Zumkehr
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Guillaume Beilleau
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Annika Kratzel
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Kimberly Schmied
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Sarah Ochsenbein
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Reto M. Lang
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Manon Wider
- Institute for Infectious Diseases, University of Bern
- Carlos Machahua
- Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern
- Patrick Dorn
- Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern
- Thomas M. Marti
- Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern
- Manuela Funke-Chambour
- Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern
- Andri Rauch
- Multidisciplinary Center for Infectious Diseases, University of Bern
- Marek Widera
- Institute of Medical Virology, University Hospital Frankfurt, Goethe University
- Sandra Ciesek
- Institute of Medical Virology, University Hospital Frankfurt, Goethe University
- Ronald Dijkman
- Multidisciplinary Center for Infectious Diseases, University of Bern
- Donata Hoffmann
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Marco P. Alves
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Charaf Benarafa
- Institute of Virology and Immunology, Bern and Mittelhäusern
- Martin Beer
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems
- Volker Thiel
- Institute of Virology and Immunology, Bern and Mittelhäusern
- DOI
- https://doi.org/10.1038/s41467-022-33632-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
A comprehensive characterisation of Omicron-BA.1 and VOC Delta in numerous in vitro and in vivo models uncovers the factors that led to its global dominance.
