Ramelteon Reduces Oxidative Stress by Maintenance of Lipid Homeostasis in Porcine Oocytes

Abstract

This study aimed to determine the underlying mechanism of ramelteon on the competence of oocyte and subsequent embryo development in pigs during in vitro maturation (IVM). Our results showed that the cumulus expansion index was significantly lower in the control group compared to the ramelteon groups (p −11 and 10−9 M ramelteon significantly increased the cumulus expansion and development-related genes expression, and reduced apoptosis in cumulus cells (p −11, 10−9, and 10−7 M ramelteon groups compared to the control (p −11 and 10−9 M ramelteon (p −11 M ramelteon compared to the control (p −11 M ramelteon group compared to the control (p −11 M ramelteon (p −11 M ramelteon compared to the control (p −11 M ramelteon during IVM improved the oocyte maturation and subsequent embryo development by reducing oxidative stress and maintenance of lipid homeostasis.

Keywords

• ramelteon
• oocyte maturation
• oxidative stress
• lipid homeostasis
• pig