Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood

Łukasz J. Sznajder; Marina M. Scotti; Jihae Shin; Katarzyna Taylor; Franjo Ivankovic; Curtis A. Nutter; Faaiq N. Aslam; S. H. Subramony; Laura P. W. Ranum; Maurice S. Swanson

doi:10.1038/s41467-020-15962-x

Nature Communications (Apr 2020)

Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood

Łukasz J. Sznajder,
Marina M. Scotti,
Jihae Shin,
Katarzyna Taylor,
Franjo Ivankovic,
Curtis A. Nutter,
Faaiq N. Aslam,
S. H. Subramony,
Laura P. W. Ranum,
Maurice S. Swanson

Affiliations

Łukasz J. Sznajder: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Marina M. Scotti: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Jihae Shin: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Katarzyna Taylor: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Franjo Ivankovic: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Curtis A. Nutter: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Faaiq N. Aslam: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
S. H. Subramony: Department of Neurology, Center for NeuroGenetics, University of Florida, College of Medicine
Laura P. W. Ranum: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Maurice S. Swanson: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine

DOI: https://doi.org/10.1038/s41467-020-15962-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The activity of the RNA splicing factor MBNL1 is altered in myotonic dystrophy (DM) patients. Here the authors characterize the thymic phenotype of Mbnl1 knockout mice, including developmental defects, transcriptome changes, and RNA mis-splicing of transcripts encoding thymic transcription factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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