The Use of Bruton Tyrosine Kinase Inhibitors in Waldenström’s Macroglobulinemia

Abstract

Abstract The use of Bruton Tyrosine Kinase (BTK) inhibitors in Waldenström’s Macroglobulinemia (WM) is evolving. Ibrutinib, a first-generation BTK inhibitor, is currently approved for use in frontline and relapsed/refractory disease. Second-generation BTK inhibitors are being used and studied to improve clinical outcomes and/or safety profile. Zanubrutinib, one such second-generation inhibitor, was recently approved in treatment-naive and refractory/relapsed patients. Here, we review the use of BTK inhibitors in WM in front-line and refractory or relapsed settings. We also highlight common adverse events, the emergence of BTK inhibitors resistance, and future directions of their use.

Keywords

• Waldenstrom’s Macroglobulinemia
• Bruton tyrosine kinase inhibitors
• Ibrutinib
• Zanubrutinib