The structure of the serotonin system: A PET imaging study

Vincent Beliveau; Brice Ozenne; Stephen Strother; Douglas N. Greve; Claus Svarer; Gitte Moos Knudsen; Melanie Ganz

NeuroImage (Jan 2020)

The structure of the serotonin system: A PET imaging study

Vincent Beliveau,
Brice Ozenne,
Stephen Strother,
Douglas N. Greve,
Claus Svarer,
Gitte Moos Knudsen,
Melanie Ganz

Affiliations

Vincent Beliveau: Neurobiology Research Unit, Copenhagen, Denmark
Brice Ozenne: Neurobiology Research Unit, Copenhagen, Denmark; Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark
Stephen Strother: Rotman Research Institute, Baycrest, and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Douglas N. Greve: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA
Claus Svarer: Neurobiology Research Unit, Copenhagen, Denmark
Gitte Moos Knudsen: Neurobiology Research Unit, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Melanie Ganz: Neurobiology Research Unit, Copenhagen, Denmark; Department of Computer Science, University of Copenhagen, Copenhagen, Denmark; Corresponding author. Neurobiology Research Unit, Copenhagen, Denmark.

Journal volume & issue: Vol. 205
p. 116240

Abstract

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The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

Published in NeuroImage

ISSN: 1053-8119 (Print); 1095-9572 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage

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