Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

Shinya Matsuda; Jonas V. Schaefer; Yusuke Mii; Yutaro Hori; Dimitri Bieli; Masanori Taira; Andreas Plückthun; Markus Affolter

doi:10.1038/s41467-021-26726-6

Nature Communications (Nov 2021)

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

Shinya Matsuda,
Jonas V. Schaefer,
Yusuke Mii,
Yutaro Hori,
Dimitri Bieli,
Masanori Taira,
Andreas Plückthun,
Markus Affolter

Affiliations

Shinya Matsuda: Biozentrum, University of Basel
Jonas V. Schaefer: Department of Biochemistry, University of Zurich
Yusuke Mii: National Institute for Basic Biology and Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences
Yutaro Hori: Institute for Quantitative Biosciences, The University of Tokyo
Dimitri Bieli: Biozentrum, University of Basel
Masanori Taira: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Andreas Plückthun: Department of Biochemistry, University of Zurich
Markus Affolter: Biozentrum, University of Basel

DOI: https://doi.org/10.1038/s41467-021-26726-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Morphogens disperse to pattern tissues and control their growth during development, allowing for the specification of multiple fates across space. Here the authors block dispersal of a morphogen Dpp (BMP2/4) and show that the requirement for Dpp dispersal is much lower than previously thought.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal