Nature Communications (Nov 2017)
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability
- Cornelia Jäkel,
- Frank Bergmann,
- Reka Toth,
- Yassen Assenov,
- Daniel van der Duin,
- Oliver Strobel,
- Thomas Hank,
- Günter Klöppel,
- Craig Dorrell,
- Markus Grompe,
- Joshua Moss,
- Yuval Dor,
- Peter Schirmacher,
- Christoph Plass,
- Odilia Popanda,
- Peter Schmezer
Affiliations
- Cornelia Jäkel
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Frank Bergmann
- Institute of Pathology, University Hospital Heidelberg
- Reka Toth
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Yassen Assenov
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Daniel van der Duin
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Oliver Strobel
- Department of General and Visceral Surgery, University Hospital Heidelberg
- Thomas Hank
- Department of General and Visceral Surgery, University Hospital Heidelberg
- Günter Klöppel
- Institute of Pathology, Technical University Munich
- Craig Dorrell
- Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health and Science University
- Markus Grompe
- Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health and Science University
- Joshua Moss
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Yuval Dor
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Peter Schirmacher
- Institute of Pathology, University Hospital Heidelberg
- Christoph Plass
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Odilia Popanda
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Peter Schmezer
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-017-01118-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and cell cycle control.
