Small cell pattern of ALK‐negative anaplastic large cell lymphoma with double‐hit rearrangements of DUSP22 and TP63

Yui Niiyama‐Uchibori; Shinsuke Mizutani; Taku Tsukamoto; Haruya Okamoto; Daisuke Ide; Akio Onishi; Daishi Kato; Takahiro Fujino; Yuji Shimira; Aya Miyagawa‐Hayashino; Eiichi Konishi; Kennosuke Karube; Yasuhito Nannya; Junya Kuroda

doi:10.1002/jha2.960

eJHaem (Aug 2024)

Small cell pattern of ALK‐negative anaplastic large cell lymphoma with double‐hit rearrangements of DUSP22 and TP63

Yui Niiyama‐Uchibori,
Shinsuke Mizutani,
Taku Tsukamoto,
Haruya Okamoto,
Daisuke Ide,
Akio Onishi,
Daishi Kato,
Takahiro Fujino,
Yuji Shimira,
Aya Miyagawa‐Hayashino,
Eiichi Konishi,
Kennosuke Karube,
Yasuhito Nannya,
Junya Kuroda

Affiliations

Yui Niiyama‐Uchibori: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Shinsuke Mizutani: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Taku Tsukamoto: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Haruya Okamoto: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Daisuke Ide: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Akio Onishi: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Daishi Kato: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Takahiro Fujino: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Yuji Shimira: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan
Aya Miyagawa‐Hayashino: Department of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan
Eiichi Konishi: Department of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan
Kennosuke Karube: Department of Pathology and Laboratory Medicine Nagoya University Graduate School of Medicine Nagoya Japan
Yasuhito Nannya: Division of Hematopoietic Disease Control Institute of Medical Science The University of Tokyo Tokyo Japan
Junya Kuroda: Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan

DOI: https://doi.org/10.1002/jha2.960
Journal volume & issue: Vol. 5, no. 4
pp. 798 – 801

Abstract

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Abstract In ALK‐negative anaplastic large cell lymphoma (ALCL), gene rearrangements of DUSP22 and TP63 are considered mutually exclusive. The former predicts a favorable prognosis, while the latter is generally unfavorable. We report the first case of ALK‐negative ALCL in a leukemic phase with small cell pattern transformation, harboring double‐hit rearrangements of the DUSP22 gene by inv(6)(p25q21) and TP63 gene by TBL1XR1‐TP63 inversion. Despite the resistance to chemotherapies, the patient remained in remission with allogeneic stem cell transplantation over 20 months. Recognizing this pathologically and genetically rare condition is needed for prompt diagnosis and therapeutic decision‐making in ALK‐negative ALCL.

Published in eJHaem

ISSN: 2688-6146 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/26886146

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