Nature Communications (Feb 2020)
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing
- Lili Yu,
- Jinchul Kim,
- Lei Jiang,
- Bingbing Feng,
- Yue Ying,
- Kai-yuan Ji,
- Qingshuang Tang,
- Wancheng Chen,
- Taoyi Mai,
- Wenlong Dou,
- Jianlong Zhou,
- Le-yang Xiang,
- Yang-fan He,
- Dinghua Yang,
- Qingjiao Li,
- Xuemei Fu,
- Yang Xu
Affiliations
- Lili Yu
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Jinchul Kim
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Lei Jiang
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Bingbing Feng
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Yue Ying
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Kai-yuan Ji
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Qingshuang Tang
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Wancheng Chen
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Taoyi Mai
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Wenlong Dou
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Jianlong Zhou
- Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University
- Le-yang Xiang
- Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University
- Yang-fan He
- Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Dinghua Yang
- Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University
- Qingjiao Li
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Xuemei Fu
- The Eighth Affiliated Hospital, Sun Yat-sen University
- Yang Xu
- The Eighth Affiliated Hospital, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-020-14437-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Aberrant alternative splicing has been shown to contribute to the tumorigenic processes. Here, the authors show that MTR4 is overexpressed in hepatocellular carcinoma and has a role in tumorigenesis through the modulation of the splicing of glycolytic genes PKM2 and GLUT1.
