Nature Communications (Jun 2022)
Lsm7 phase-separated condensates trigger stress granule formation
- Michelle Lindström,
- Lihua Chen,
- Shan Jiang,
- Dan Zhang,
- Yuan Gao,
- Ju Zheng,
- Xinxin Hao,
- Xiaoxue Yang,
- Arpitha Kabbinale,
- Johannes Thoma,
- Lisa C. Metzger,
- Deyuan Y. Zhang,
- Xuefeng Zhu,
- Huisheng Liu,
- Claes M. Gustafsson,
- Björn M. Burmann,
- Joris Winderickx,
- Per Sunnerhagen,
- Beidong Liu
Affiliations
- Michelle Lindström
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Lihua Chen
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Shan Jiang
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Dan Zhang
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Yuan Gao
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Ju Zheng
- Functional Biology, KU Leuven
- Xinxin Hao
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Xiaoxue Yang
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Arpitha Kabbinale
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Johannes Thoma
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Lisa C. Metzger
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Deyuan Y. Zhang
- College of Artificial Intelligence, Shenyang Aerospace University, Shenbei New District
- Xuefeng Zhu
- Department of Medical Biochemistry and Cell Biology, University of Gothenburg
- Huisheng Liu
- Guangzhou Laboratory
- Claes M. Gustafsson
- Department of Medical Biochemistry and Cell Biology, University of Gothenburg
- Björn M. Burmann
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Joris Winderickx
- Functional Biology, KU Leuven
- Per Sunnerhagen
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Beidong Liu
- Department of Chemistry and Molecular Biology, University of Gothenburg
- DOI
- https://doi.org/10.1038/s41467-022-31282-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Stress granules are non-membranous organelles connected to stress responses and age-related disease. Here, the authors identify a conserved yeast protein, Lsm7, that facilitates stress granule formation through dynamic liquid-liquid phase separation condensates upon 2-deoxy-D-glucose-induced stress.
