European Psychiatry (Jan 2023)
Does social cognition change? Evidence after 4 years from the Italian Network for Research on Psychoses
- Paola Rocca,
- Paola Rucci,
- Cristiana Montemagni,
- Alessandro Rossi,
- Alessandro Bertolino,
- Eugenio Aguglia,
- Carlo A. Altamura,
- Mario Amore,
- Ileana Andriola,
- Antonello Bellomo,
- Claudio Brasso,
- Bernardo Carpiniello,
- Elisa Del Favero,
- Liliana Dell’Osso,
- Fabio Di Fabio,
- Michele Fabrazzo,
- Andrea Fagiolini,
- Giulia Maria Giordano,
- Carlo Marchesi,
- Giovanni Martinotti,
- Palmiero Monteleone,
- Maurizio Pompili,
- Rita Roncone,
- Rodolfo Rossi,
- Alberto Siracusano,
- Elena Tenconi,
- Antonio Vita,
- Patrizia Zeppegno,
- Silvana Galderisi,
- Mario Maj
Affiliations
- Paola Rocca
- ORCiD
- Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy
- Paola Rucci
- Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
- Cristiana Montemagni
- Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy
- Alessandro Rossi
- ORCiD
- Section of Psychiatry, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
- Alessandro Bertolino
- Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
- Eugenio Aguglia
- Psychiatry Unit, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy
- Carlo A. Altamura
- Department of Psychiatry, University of Milan, Milan, Italy
- Mario Amore
- Section of Psychiatry, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy
- Ileana Andriola
- ORCiD
- Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
- Antonello Bellomo
- ORCiD
- Psychiatry Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy
- Claudio Brasso
- ORCiD
- Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy
- Bernardo Carpiniello
- ORCiD
- Section of Psychiatry, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy
- Elisa Del Favero
- Section of Psychiatry, Department of Neuroscience, University of Turin, Turin, Italy
- Liliana Dell’Osso
- ORCiD
- Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
- Fabio Di Fabio
- ORCiD
- Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
- Michele Fabrazzo
- ORCiD
- Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Andrea Fagiolini
- Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, Italy
- Giulia Maria Giordano
- Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Carlo Marchesi
- Psychiatry Unit, Department of Neuroscience, University of Parma, Parma, Italy
- Giovanni Martinotti
- ORCiD
- Department of Neuroscience and Imaging, G. D’Annunzio University, Chieti, Italy
- Palmiero Monteleone
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Section of Neuroscience, University of Salerno, Salerno, Italy
- Maurizio Pompili
- ORCiD
- Department of Neurosciences, Mental Health and Sensory Organs, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy
- Rita Roncone
- ORCiD
- Unit of Psychiatry, Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy
- Rodolfo Rossi
- ORCiD
- Section of Psychiatry, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
- Alberto Siracusano
- ORCiD
- Psychiatry and Clinical Psychology Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy
- Elena Tenconi
- ORCiD
- Psychiatric Clinic, Department of Neurosciences, University of Padua, Padua, Italy
- Antonio Vita
- Psychiatric Unit, School of Medicine, University of Brescia, Brescia, Italy Department of Mental Health, Spedali Civili Hospital, Brescia, Italy
- Patrizia Zeppegno
- ORCiD
- Psychiatric Unit, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
- Silvana Galderisi
- ORCiD
- Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Mario Maj
- ORCiD
- Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- DOI
- https://doi.org/10.1192/j.eurpsy.2022.2356
- Journal volume & issue
-
Vol. 66
Abstract
Abstract Background Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up. Methods The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up. Results In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery. Conclusions The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.
Keywords
- Follow-up
- recovery
- reliable and clinically significant change (RCSC)
- schizophrenia
- social cognition
- theory of mind
