A Mesoscopic Simulation Study on the Solubilization of Menthol by Platycodin D

Abstract

Mesodyn simulation is employed in this research to investigate the influences of temperature on the solubilization of menthol by platycodin D. The results show that the crucial factor on the speed of solubilization of menthol is the time for micellization of platycodin D. Increase in temperature is not conducive to the micellization of platycodin D, but it may have a positive effect on the diffusion of menthol into platycodin D micelles. Considering both the speed and efficiency of the solubilization of menthol by platycodin D, there exists an optimum temperature for the preparation process. This work offers abundant information at the mesoscopic level and may serve as guidance for the solubilization of volatile oil in medicine preparation.

Keywords

• Mesodyn
• menthol
• platycodin D
• temperature
• solubilization