A strategy to discover new organizers identifies a putative heart organizer

Claire Anderson; Mohsin A. F. Khan; Frances Wong; Tatiana Solovieva; Nidia M. M. Oliveira; Richard A. Baldock; Cheryll Tickle; Dave W. Burt; Claudio D. Stern

doi:10.1038/ncomms12656

Nature Communications (Aug 2016)

A strategy to discover new organizers identifies a putative heart organizer

Claire Anderson,
Mohsin A. F. Khan,
Frances Wong,
Tatiana Solovieva,
Nidia M. M. Oliveira,
Richard A. Baldock,
Cheryll Tickle,
Dave W. Burt,
Claudio D. Stern

Affiliations

Claire Anderson: Department of Cell and Developmental Biology, University College London
Mohsin A. F. Khan: Department of Cell and Developmental Biology, University College London
Frances Wong: Department of Genomics and Genetics, The Roslin Institute, University of Edinburgh, Easter Bush
Tatiana Solovieva: Department of Cell and Developmental Biology, University College London
Nidia M. M. Oliveira: Department of Cell and Developmental Biology, University College London
Richard A. Baldock: Biomedical Systems Analysis Section, MRC Human Genetics Unit, IGMM, University of Edinburgh
Cheryll Tickle: Department of Biology & Biochemistry, University of Bath
Dave W. Burt: Department of Genomics and Genetics, The Roslin Institute, University of Edinburgh, Easter Bush
Claudio D. Stern: Department of Cell and Developmental Biology, University College London

DOI: https://doi.org/10.1038/ncomms12656
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Organizers are regions in the embryo that induce cell fate and impart pattern on neighbouring regions. Here, the authors search for new organizers based on a common gene signature, and show that the Anterior Intestinal Portal endoderm induces cardiac identity, specifies ventricle and inhibits atrial character.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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