Structural insights into TSC complex assembly and GAP activity on Rheb

Huirong Yang; Zishuo Yu; Xizi Chen; Jiabei Li; Ningning Li; Jiaxuan Cheng; Ning Gao; Hai-Xin Yuan; Dan Ye; Kun-Liang Guan; Yanhui Xu

doi:10.1038/s41467-020-20522-4

Nature Communications (Jan 2021)

Structural insights into TSC complex assembly and GAP activity on Rheb

Huirong Yang,
Zishuo Yu,
Xizi Chen,
Jiabei Li,
Ningning Li,
Jiaxuan Cheng,
Ning Gao,
Hai-Xin Yuan,
Dan Ye,
Kun-Liang Guan,
Yanhui Xu

Affiliations

Huirong Yang: Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University
Zishuo Yu: Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University
Xizi Chen: Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University
Jiabei Li: Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University
Ningning Li: State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University
Jiaxuan Cheng: State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University
Ning Gao: State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University
Hai-Xin Yuan: The Molecular and Cell Biology Research Lab, The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University
Dan Ye: The Molecular and Cell Biology Research Lab, The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University
Kun-Liang Guan: Department of Pharmacology and Moores Cancer Center, University of California San Diego
Yanhui Xu: Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University

DOI: https://doi.org/10.1038/s41467-020-20522-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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