Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia

Anemut Tilahun; Endeshaw Chekol; Awgchew Behaile Teklemaryam; Melaku Mekonnen Agidew; Zelalem Tilahun; Fitalew Tadele Admassu; Nega Dagnaw; Misganaw Asmamaw Mengstie; Alebachew Amsalu; Enyew Fenta Mengistu; Yibeltal Akelew; Tadesse Asmamaw; Berihun Bantie

Heliyon (Nov 2022)

Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia

Anemut Tilahun,
Endeshaw Chekol,
Awgchew Behaile Teklemaryam,
Melaku Mekonnen Agidew,
Zelalem Tilahun,
Fitalew Tadele Admassu,
Nega Dagnaw,
Misganaw Asmamaw Mengstie,
Alebachew Amsalu,
Enyew Fenta Mengistu,
Yibeltal Akelew,
Tadesse Asmamaw,
Berihun Bantie

Affiliations

Anemut Tilahun: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; Corresponding author.
Endeshaw Chekol: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Awgchew Behaile Teklemaryam: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Melaku Mekonnen Agidew: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Zelalem Tilahun: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Fitalew Tadele Admassu: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Nega Dagnaw: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Misganaw Asmamaw Mengstie: Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Alebachew Amsalu: Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Enyew Fenta Mengistu: Department of Biomedical Sciences, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Yibeltal Akelew: Department of Medical Laboratory, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia
Tadesse Asmamaw: Department of Biochemistry, College of Health Sciences, Gondar University, Gondar, Ethiopia
Berihun Bantie: Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia

Journal volume & issue: Vol. 8, no. 11
p. e11342

Abstract

Read online

Background: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder. Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patients was conducted from July to August 2020. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was collected and analyzed for Lipid profiles. EDTA sample was analyzed for CD4+ T cell determination. Anthropometric measurement was done. Data were analyzed using SPSS version 22. Independent t-test was done. Logistic and binary regression was done. Result: A total of 228 HIV patients were enrolled in the study. Prevalence of dyslipidemia in HAART naive and HAART treated patients was 61 (53.5%) and 84 (73.7%), respectively. The prevalence of Total Cholesterol ≥200 mg/dl was 50% and 30%; High density lipoprotein cholesterol 25 kg/m2 (AOR = 1.92, 95% C.I: 1.20–4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher among HAART treated as compared to those HAART naive HIV positive clients.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

About the journal

Abstract

Keywords