The influence of obesity and insulin resistance on the progress of bronchial asthma

Abstract

Objective – to evaluate the clinical and laboratory parameters in patients with bronchial asthma and obesity based on the distribution of adipose tissue Materials and мethods. The study involved 78 patients with uncontrolled bronchial asthma with obesity (A + O). 2 groups were formed: Group 1 – 43 patients with gynoid type obesity and Group 2 – 35 patients with android type obesity. An anthropometric study: the hip circumference (HC), waist circumference (WC), the ratio of WC/HC, case history data analysis, Asthma Control Test (ACT). Blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low density lipoprotein (LDL), glycated hemoglobin test (HbAlc %), index HOMA-IR Monocyte Chemoattractant Protein-1 (MCP-1), respiratory function (RF) were examined. Results. It has been revealed the reliable increase in indices in the 2nd group: HbAlc, HOMA-IR, TG, LDL, MCP-1 p < 0.05. It has been found the decreased levels of speed indices parameters – FEV1, FEF25, FEF75 and FVC, p < 0.05. It has been found a high correlation between age and the ratio of OT/OS (r = 0.52, p < 0.05). The positive correlation between the mean force MCP-1 and TG (r = 0.56, p < 0.05) and MCP-1 and LDL (r = 0.49, p < 0.05) has been obtained. Correlation analysis of FDD and biochemical parameters: blood glucose (r = 0.26, p < 0.05), TG (r = 0.27, p < 0.051), the index NOMA-IR (r = 0.38, p <0.05), ACT (r = 0.33, p <0.05), MPC-1 (0.62, p < 0.05). Conclusions. The obtained data proves the negative impact of android type obesity on bronchial asthma course. Identified correlations between the EF and studied biochemical indicators demonstrate the carbohydrate and fat metabolism disturbances and inflammation development in patients with different types of obesity.

Keywords

• asthma
• obesity
• inflammation
• insulin resistance