Hematological Effects of Herbicide Avalon® (Bentazon+Dicamba) in Rats

Abstract

Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba,were tested on rats. Avalon was administered by gavage at three and four dose levels(250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days.Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobinconcentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) weremonitored.The results showed that the herbicide Avalon caused decrease in the values of hemoglobin,hematocrit and erythrocyte indexes (both males and females). The changes(mostly) correlated with the doses administered and, in most cases, a lower susceptibilityof females than males was observed. The herbicide GAL-57 had no adverse effect on thenumber of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested).The results showed that the herbicide Avalon causes weak anemia to the animals tested.Reversibility was apparent during the recovery period of 28 days.

Keywords

• Avalon
• Bentazon
• Dicamba
• Rat
• Subacute toxicity
• Hematological effects