Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats

Haobo Han; Jiakai Xing; Wenqi Chen; Jiaxin Jia; Quanshun Li

doi:10.1038/s41467-023-36625-7

Nature Communications (Feb 2023)

Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats

Haobo Han,
Jiakai Xing,
Wenqi Chen,
Jiaxin Jia,
Quanshun Li

Affiliations

Haobo Han: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University
Jiakai Xing: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University
Wenqi Chen: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University
Jiaxin Jia: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University
Quanshun Li: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University

DOI: https://doi.org/10.1038/s41467-023-36625-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

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Delivery of anti-inflammatory microRNA (miRNA) could be beneficial for inflammatory diseases such as rheumatoid arthritis (RA). Here the authors show that a fluorinated polyamidoamine dendrimer nanoparticle delivers miR-23b to affected RA joints and reduces inflammation, joint damage and synovial cell influx.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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