Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord

Abstract

Background.Spinal cord ischemia (SCI) is accompanied by severepersistent neurological and physical disorders. The articlediscusses potential neuroprotective effect of L-lysine aescinat. Objective.to assess the effect of L-lysine aescinat on the functionalrecovery and morphological picture of spinal cord in whiterats with simulated SCI. Methods. Spinal cord ischemia was induced by ligation of the infrarenalabdominal aorta in two experimental groups of rats. Inthe control group (n=8), aorta was ligated; in the experimentalgroup (n=8), L-lysine aescinat was injected intraperitoneally ata dose of 0.14 mg/kg 30 minutes before ischemia, followed byligation of aorta. Results.Pronounced and statistically significant neuroprotectiveeffect of L-lysine aescinat was demonstrated, which clinicallymanifested as neurological deficit reduction and morphologicallymanifested as increased number of normochromic neurons and decreasednumber of shrunken neurons and shadow-cells (p0.01), aswell as suppression of edema of the spinal cord substance. Conclusion.L-lysine aescinat has a neuroprotective effect in ratswith experimental ischemia of the spinal cord.

Keywords

• spinal cord
• ischemia
• model
• neurons
• l-lysine aescinat