Journal of International Medical Research (Jan 2020)

Serial optical coherence tomography and angioscopic assessments of 10-year in-stent restenosis of Cypher sirolimus-eluting stent treated with drug-coated balloon angioplasty

  • Satoshi Suzuki,
  • Shimpei Nakatani,
  • Yohei Sotomi,
  • Ichiro Shiojima,
  • Yasushi Sakata,
  • Yoshiharu Higuchi

DOI
https://doi.org/10.1177/0300060519837445
Journal volume & issue
Vol. 48

Abstract

Read online

The drug-coated balloon (DCB) angioplasty is considered a standard therapeutic option for in-stent restenosis. In the present case, we observed high-intensity spots on optical coherence tomography (OCT) and bright spots on coronary angioplasty (CAS) immediately after DCB angioplasty. The superficial high-intensity area on OCT presumably corresponded with the bright spots on CAS. The high-intensity superficial regions were thought to represent an iopromide/paclitaxel mixture. The present serial observation demonstrated that the eluted drugs remained for at least 2 months but disappeared within 6 months. At the site where we observed the drugs, neointimal growth was successfully inhibited and stabilized at the 6-month follow-up. The association of eluted drugs after DCB angioplasty with consequent neointimal growth is of scientific interest. Further prospective imaging studies with a large sample size are warranted to clarify this association.