Superficial X-ray radiotherapy combined with cryotherapy is effective and safe for multiple verruca vulgaris

Abstract

Objective To observe the efficacy and safety of superficial X-ray radiotherapy combined with liquid nitrogen cryotherapy in the treatment of multiple verruca vulgaris. Methods From November 2017 to May 2020, a total of 114 patients with multiple verruca vulgaris admitted to our dermatology clinic were randomly assigned to two groups, i.e. 57 cases in the control group treated with liquid nitrogen alone, and 57 cases in the treatment group treated with both liquid nitrogen and SRT-100 superficial X-ray radiotherapy. The overall effective rate, cure score, recurrence rate and adverse reaction rate were compared between the two groups. Results After the treatments, the overall effective rate was higher in the treatment group than in the control group (94.74% vs. 80.70%, χ2=5.21, P<0.05). Similarly, the cure score was higher in the treatment group than in the control group (6.11±1.45 vs. 5.46±1.51, t=2.34, P<0.05). In contrast, the recurrence rate was lower in the treatment group than in the control group (14.04% vs. 43.86%, χ2=12.33, P<0.01). The rates of adverse reactions in the treatment and control groups were 10.53% and 26.32% (χ2=4.73, P=0.030), respectively. Conclusions Superficial X-ray radiotherapy combined with liquid nitrogen cryotherapy is effective in the treatment of multiple verruca vulgaris. It can significantly improve the overall effective rate and lower the recurrence rate and adverse reaction rate.

Keywords

• multiple verruca vulgaris
• superficial x-ray radiotherapy
• liquid nitrogen cryotherapy
• combination therapy