Nature Communications (Jan 2023)

BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases

  • Saaket Agrawal,
  • Marcus D. R. Klarqvist,
  • Nathaniel Diamant,
  • Takara L. Stanley,
  • Patrick T. Ellinor,
  • Nehal N. Mehta,
  • Anthony Philippakis,
  • Kenney Ng,
  • Melina Claussnitzer,
  • Steven K. Grinspoon,
  • Puneet Batra,
  • Amit V. Khera

DOI
https://doi.org/10.1038/s41467-022-35704-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 10

Abstract

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Different location of adipose tissue may have different consequences to cardiometabolic risk. Here the authors report that deep learning enabled accurate prediction of specific adipose tissue volumes, and that after adjustment for BMI, visceral adiposity was associated with increased risk of cardiometabolic disease, while gluteofemoral adiposity was associated with reduced risk.