Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

Abstract

The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex plays an essential role in gene regulation. Here, the authors report two structures of the human and yeast Ctr9/Paf1 subcomplexes, and find that this is essential for Paf1 complex assembly and function.