The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease

Abstract

Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin (PGRN) is defined as precursor of pleiotropic glycosylated protein, it has significant role in process of inflammation, angiogenesis, neoplasia, cell development, cell cycle, embryogenesis, wound healing, modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and inflammatory markers in COPD patients. Material and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test, blood investigation include CRP-titer, WBC and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: The study showed that, there was no significant correlation between serum progranulin level, WBC and C-Reactive Protein titer in COPD patients (P value >0.05). Conclusions: It was concluded that PGRN level in COPD patients don’t correlate with CRP titer level or with WBC.

Keywords

• Chronic obstructive pulmonary disease
• Progranulin
• C-Reactive Protein
• Spirometry,