In-vitro antibacterial, antioxidant and cytotoxic potential of gold nanoparticles synthesized using novel Elaeocarpus ganitrus seeds extract

Abstract

In the present study, we have follwed the hydrothermal path for the synthesis of gold nanoparticles (Au NPs) from the biomaterial Elaeocarpus ganitrus seeds extract, which is a rapid, eco-friendly, non-chemical way. The prepared NPs were thoroughly analysed by powder x-ray diffraction and high resolution transmission electron microscopy studies and were also tested for anticancer studies. Besides, the antioxidant, antibacterial and anticancer properties of Au NPs were studied. In vitro studies revealed the dose-dependent cytotoxic effect of Au NPs. The prepared nanoparticles showed good cytotoxic impact against a prostate cancer (PC-3) cells line. The evidences of the current study lead to the synthesis of novel and cost-effective drugs from Elaeocarpus ganitrus seeds extract by using the bio approach.

Keywords

• Elaeocarpu sganitrus
• Hydrothermal synthesis
• Gold nanoparticles
• Prostate cancer
• Cancer nanomedicine